BioNTech

Note: This is a daily stock update and the information stands true as of 08/09/25, 09:00 CET.

Company Update:
BioNTech's ADR rose c.9% on Friday following the announcement that BioNTech and its partner, Duality Biologics, achieved the primary endpoint of progression-free survival in an interim analysis of their Phase 3 trial in China. The trial involved their antibody-drug conjugate (ADC), Trastuzumab pamirtecan, targeting HER2-positive unresectable or metastatic breast cancer. An independent data monitoring committee indicated that patients receiving this experimental ADC experienced longer progression-free survival compared to Roche's ADC. The drug will also compete with AstraZeneca and Daiichi Sankyo's Enhertu.
The companies plan to seek approval in China, a market with significant growth potential, as over 350,000 women are diagnosed with breast cancer annually. Additionally, the complete dataset and results from the global Phase 3 trial could facilitate potential approvals in the US and EU. Overall, this drug has the potential to become a multi-blockbuster for both companies.

Expert Opinion: 
Our analyst on the name is quite positive on BioNTech and indeed that kind of news is positive for any biotech. This could be a negative X read for Roche which has a similar drug. Our expert still struggles with the valuation (loss making for the next three years) and an EV/Sales ratio around 5x. He suggests you have a call with our analyst on the name if you want to know more about the prospects of the company.


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